A Trial of Trimethoprim-Sulfamethoxazole in Pregnancy to Improve Birth Outcomes.
懷孕期間使用 Trimethoprim-Sulfamethoxazole 改善出生結局之試驗
N Engl J Med 2025-06-04
Claudin-18 isoform 2-specific CAR T-cell therapy (satri-cel) versus treatment of physician's choice for previously treated advanced gastric or gastro-oesophageal junction cancer (CT041-ST-01): a randomised, open-label, phase 2 trial.
Claudin-18 isoform 2 專一性 CAR T 細胞治療(satri-cel)對比醫師自選治療於既往治療過的晚期胃癌或胃食道接合部癌(CT041-ST-01):一項隨機、開放標籤、第二期臨床試驗
Lancet 2025-06-03
中國一項二期臨床試驗顯示,針對晚期胃癌或胃食道接合處癌且前兩線治療失敗的患者,satri-cel(CLDN18.2 CAR T 細胞治療)在延長無惡化存活期上明顯優於標準治療,但副作用如血球下降和細胞激素釋放症候群較多。這是首個針對實體腫瘤的 CAR T 細胞隨機試驗,證實 satri-cel 是第三線治療的新選擇。
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以可測量殘留疾病(Measurable Residual Disease, MRD)指引治療於新診斷多發性骨髓瘤的應用
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JAMA 2025-06-02