Prolonged signaling of backbone-modified glucagon-like peptide-<b>1</b> analogues with diverse receptor trafficking.
延長背骨修飾的胰高血糖素樣肽-1類似物的信號傳遞及其多樣的受體運輸。
Proc Natl Acad Sci U S A 2025-04-01
Control of human pancreatic beta cell kinome by glucagon-like peptide-1 receptor biased agonism.
葡萄糖樣肽-1受體偏倚激動劑對人胰島β細胞激酶組的控制。
Diabetes Obes Metab 2024-03-20
Structure and Molecular Mechanism of Signaling for the Glucagon-like Peptide-1 Receptor Bound to Gs Protein and Exendin-P5 Biased Agonist.
胰高血糖素樣肽-1受體與Gs蛋白及Exendin-P5偏向性激動劑結合的結構和信號傳遞的分子機制。
J Am Chem Soc 2024-01-11
GLP-1R signaling neighborhoods associate with the susceptibility to adverse drug reactions of incretin mimetics.
GLP-1R信號傳遞鄰域與胰高血糖素類藥物不良藥物反應易感性相關。
Nat Commun 2024-02-10
Computational modelling of dynamic cAMP responses to GPCR agonists for exploration of GLP-1R ligand effects in pancreatic β-cells and neurons.
胰島素β細胞和神經元中 GPCR 激動劑引起的動態 cAMP 反應的計算模擬，用於探索 GLP-1R 配體對其效應。
Cell Signal 2024-05-09
The G Protein-First Mechanism for Activation of the Class B Glucagon-like Peptide 1 Receptor Coupled to N-Terminal Domain-Mediated Conformational Progression.
G 蛋白優先機制在 N 端結構域介導的構象進展中激活 Class B Glucagon-like Peptide 1 受體。
J Am Chem Soc 2024-09-12
Design, Structure-Activity Relationships, and Computational Modeling Studies of a Series of α-Helix Biased, Ultra-Short Glucagon-like Peptide-1 Receptor Agonists.
α-螺旋偏向的超短型胰高血糖素樣肽-1受體激動劑的設計、結構-活性關係及計算模型研究。
Molecules 2025-01-11
Effect of Lipidation on the Structure, Oligomerization, and Aggregation of Glucagon-like Peptide 1.
脂質化對胰高血糖素樣肽1的結構、聚合及聚集的影響。
Bioconjug Chem 2025-01-22
A New Protractor Potentiates Glucagon-Like Peptide 1 with Slow-Release Depot and Long-Term Action.
一種新型的測角器增強了胰高血糖素樣肽1的緩釋儲存和長期作用。
J Med Chem 2025-03-21