A sub-study of the POISE-3 randomized trial examined effects of a perioperative hypotension-avoidance strategy versus a hypertension-avoidance strategy on the risk of acute kidney injury.
POISE-3 隨機試驗的子研究探討了圍手術期避免低血壓策略與避免高血壓策略對急性腎損傷風險的影響。
Kidney Int 2024-11-04
在POISE-3試驗的子研究中,研究人員探討了兩種圍手術期策略對7307名高風險患者術後急性腎損傷(AKI)風險的影響。避免低血壓的策略目標是維持平均動脈壓(MAP)在80 mm Hg以上,而避免高血壓則是保持MAP在60 mm Hg以上。結果顯示,雖然避免低血壓組使用的降壓藥物較少,且低於80 mm Hg的時間也較短,但兩組的AKI風險並無顯著差異(分別為15.1%和14.4%)。因此,避免低血壓的策略並未降低AKI風險。
PubMedDOI♡
站上相關主題文章列表
Breaking Down the Evidence: Does Perioperative Hypotension Cause Kidney Injury?
解析證據:围手术期低血壓是否會導致腎損傷?
Nephron 2023-12-16
Continuation vs Discontinuation of Renin-Angiotensin System Inhibitors Before Major Noncardiac Surgery: The Stop-or-Not Randomized Clinical Trial.
在重大非心臟手術前持續使用與停止使用腎素-血管緊張素系統抑制劑:Stop-or-Not 隨機臨床試驗。
JAMA 2024-08-30
Cardiac Surgery-Associated Acute Kidney Injury in Cardiopulmonary Bypass: A Focus on Sex Differences and Preventive Strategies.
心臟手術相關的急性腎損傷與心肺旁路:聚焦性別差異及預防策略。
Am J Physiol Renal Physiol 2024-10-17
Higher intraoperative blood pressure does not reduce acute kidney injury in non-cardiac surgery: what do the results of the POISE-3 trial tell us?
非心臟手術中較高的術中血壓並不減少急性腎損傷:POISE-3 試驗的結果告訴我們什麼?
Kidney Int 2024-11-04
Treatment Effect Heterogeneity in Acute Kidney Injury Incidence Following Intravenous Antihypertensive Administration for Severe Blood Pressure Elevation During Hospitalization.
住院期間因嚴重血壓升高而接受靜脈抗高血壓藥物治療後急性腎損傷發生率的治療效果異質性。
Am J Kidney Dis 2024-11-23