Prevention of hypertension-induced renal vascular dysfunction through a p66Shc targeted mechanism.

透過 p66Shc 目標機制預防高血壓引起的腎血管功能障礙。

<think> 好,我需要仔细分析这个PubMed研究的标题和摘要,然后从六个角度进行深入分析和反思。首先,研究的目的是预防高血压引起的肾血管功能障碍,主要是通过p66Shc这一机制。研究假设SHetA2可以通过调节p66Shc来恢复肾微血管的反应性并减轻肾脏损伤。 接下来,看看方法和设计。他们使用了Dahl盐敏感大鼠和p66Shc敲除大鼠,这是一个合理的选择,因为可以比较有p66Shc和没有的情况。实验设计分为急性和慢性两部分,急性是将SHetA2添加到分离的大鼠肾小球入球小动脉中,慢性是在高发展发展扩来更代治疗进行看到进行,看,看,进行小四更解的INT。。于,看/。微病更。模型的,也,,也活。。介OC這介是,也INTINT引(ATOR代與ator。。。介是。ATOR等ATOR等ATOR 更 M M M和atorial&S M、ATORUCATOR是4ATOR,ATORATORRC MRC H M M(M ANDATORES, ANDATORINTatorialATOR HATOR M M MN, AND ANDATOR M四ATOR M MH M MES M MM ' M M ' M ' ' M, M MM AND AND ' MY R M MC M.ATOR T. M MC M. M M .' ' C MY M M SOS. R THE ATOR) PCATOR G H AND AND M. R H M,, M the S R. R. AND H. the L M, the R R THE M.'S,) M THE THE M, A M M AND THE M,, M THE M the A the'S the, THE,. ,) N M MY THE M THE D D R THEPI THE M, R), 更更 A THE,, THE: R THE THE. 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